National Institute of Nursing Research, NIH
NIH grants RR00035 and RR00722 to the General Clinical Research Center and the JHU School of Medicine.
Total Direct Costs: $1,934,027
6/1/1997 - 2/28/2003
The CLINCH Study looked at the benefit of a nurse-managed, case-managed system of lifestyle modification and pharmacologic intervention to manage high cholesterol in adults after heart revascularization.
Meet the Investigators
Jerilyn K. Allen
• Jerilyn K. Allen, RN, ScD, FAAN, JHU School of Nursing
• Lee Bone, MPH, JHU School of Public Health
• Fred Brancati, MD, JHU School of Medicine
• Cheryl Dennison, PhD, RN, JHU School of Nursing
• Kevin Frick, PhD, JHU School of Public Health
• Martha N. Hill, PhD, RN, FAAN; Dean, JHU School of Nursing
• David Levine, MD, JHU School of Medicine
• Sarah Szanton, PhD, MSN, CRNP, JHU School of Nursing
The purpose of this randomized controlled trial was to determine the effectiveness of a nurse case management program to lower blood lipids in patients with coronary heart disease. A total of 228 hypercholesterolemic adults were recruited during hospitalization following coronary revascularization and randomized to receive lipid management, including individualized lifestyle modification and pharmacologic intervention, from a nurse practitioner for one year following discharge, in addition to their usual care (NURS) or to usual care enhanced with feedback regarding lipids to their primary provider and/or cardiologist (EUC). We found that significantly more patients in the NURS group vs. the EUC group achieved low-density lipoprotein cholesterol levels lower than 2.59 mmol/dL. Favorable changes in lipids and lipoproteins were accompanied by significant improvements in dietary and exercise patterns in the NURS group.
Allen, J.K., Blumenthal, R.S., Margolis, S., & Young, D.R. (2001). Status of secondary prevention in patients undergoing revascularization. American Journal of Cardiology, 87, 1203-1206*
Young, K., Allen, J. K., & Kelly, K. (2001). High density lipoprotein: A review of pharmacologic and nonpharmacologic influences. Clinical Reviews, 11(5), 51-59.
Becker, D.M. & Allen, J.K. (2001). Improving compliance in your dyslipidemic patient: An evidence-based approach. Journal of the American Academy of Nurse Practitioners, 13(5), 200-207.
Allen, J. K. (2000). Cholesterol management: An opportunity for nurse case managers. Journal of Cardiovascular Nursing, 14(2), 50-58.
Haymart, M.R., Allen, J.K., Blumenthal, R.S. (1999). Optimal management of dyslipidemia in women and men. The Journal of Gender-Specific Medicine, 2(6), 37-42.
Allen JK, Blumenthal RS, Margolis S, Young DR, Miller ER, Kelly K. (2002) Nurse case management of hypercholesterolemia. American Heart Journal, 144(4), 678-686.*
November 2000 Allen, J.K., Blumenthal, R. S., Margolis, S., Young D.R., Rohde, C., Kelly, K. Nurse Case Management Compared With Usual Physician Care for Lipid Management Following Revascularization. 73rd Annual Scientific Sessions, American Heart Association, New Orleans, Louisiana
Economic Analysis in Intervention Research: February, 2001 Economic Analysis in Nursing Intervention Research.15th Anniversary Conference, Southern Nursing Research Society, Baltimore, Maryland
Allen JK, Kelly K, Blumenthal RS, Margolis S, Young DR, Curtis C, Lavis A. (2002) Nurse case management of hypercholesterolemia is cost-effective. [Abstract] Circulation, 106(19), ii-369.
Allen J, Blumenthal RS, Margolis S, Young DR, Rohde C, Kelly K. (2000) Nurse case management compared with usual physician care for lipid management following revascularization. [Abstract] Circulation, 102(18), II-749.
July 2004 Allen, JK, Nurse Case Management of Hypercholesterolemia is Cost-Effective. 15th International Nursing Research Congress/International Evidence-Based Practice, Sigma Theta Tau International. Dublin, Ireland.
November 2002 Allen, JK, Kelly, K, Blumenthal, R, Margolis, S, Young, D, Curtis, C, Lavis, A. Nurse Case Management of Hypercholesterolemia is Cost Effective. Scientific Sessions, American Heart Association. Chicago, Illinois.*
November 2000 Allen, JK, Blumenthal, RS, Margolis, S, Young DR, Rohde, C, Kelly, K. Nurse case management compared with usual physician care for lipid management following revascularization. 73rd Annual Scientific Sessions, American Heart Association. New Orleans, Louisiana.*
September 2002 Allen, JK, Blumenthal, RS, Margolis, S, Miller, ER, Young, DR. A Randomized Clinical Trial of Nurse Case Management of Hyper- cholesterolemia. State of the Science Congress. Washington DC.*
September 1999 Allen, JK. CLINCH, Cholesterol Lowering Intervention by Nurses to Control Heart Disease, American Association of Cardiovascular and Pulmonary Rehabilitation. Phoenix, Arizona (invited).
February 2003 Allen JK, Kelly, KM, Blumenthal, RS, Margolis, S,Young, DR, Curtis, C, Lavis, A. Nurse Case Management of Hypercholesterolemia is Cost-effective. Southern